Subcellular Compartmentalization and Trafficking of the Biosynthetic Machinery for Fungal Melanin
Protection by melanin depends on its subcellular location.Although most filamentous fungi synthesize melanin via a polyketide synthase pathway, where and how melanin biosynthesis occurs and how it is deposited as extracellular granules remain elusive.Using a forward genetic screen in the Toddler Bottoms pathogen Aspergillus fumigatus, we find that